Modalert 200 tablet is used to decrease excessive sleepiness caused by narcolepsy. It also improves task performance. It has a mood-enhancing effect and has been tested in patients with depression. This medicine should be taken strictly as prescribed by your doctor. It is best to avoid consuming alcohol while taking this medication.
Modafinil Increases Serotonin Levels
Modafinil is a potent wakefulness agent that increases Fos-immunoreactivity in identified orexin cells in the perifornical cortex (Chemelli et al., 1999; Scammell et al., 2000). Furthermore, it induces wakefulness more effectively than the orexin agonist cyproheptadine in orexin receptor knockout mice, and unlike amphetamine, it does not increase locomotor activity, feelings of jitteriness, or appetite.
Interestingly, Modafinil also causes increases in the cerebral glutamate-glutamine pool, and these effects are block by prazosin but not yohimbine. This suggests that post-synaptic adrenergic mechanisms mediate the orexin-like effect of Modafinil. In one study, Modafinil enhanced performance on digit span and visual recognition memory tasks in healthy adults. However, it did not improve delayed matching or arithmetic working memory performance. In addition, it did not impair vigilance or speed-accuracy trade-off in attention tasks.
Modafinil Increases Dopamine Levels
Modafinil is a wakefulness agent that has show to increase dopamine levels in the brain. It is also a cognitive enhancer, and it has show to improve attention and concentration. It is also effective in treating AMP/MA addiction because it increases cognition and reduces cue- and MA-induced reinstatement of MA self-administration in rats.
It is important to note that Modalert does have abuse potential and can be habit-forming if taken in high doses or for long periods. Therefore, it is important to monitor patients for signs of misuse or abuse. Moreover, it should not be consume by people with certain medical conditions. This includes liver disease. Consuming alcohol with this drug can cause side effects like drowsiness, dizziness, and impaired judgment.
Modafinil Increases Norepinephrine Levels
Modafinil increases levels of norepinephrine in the brain, which enhances alertness and cognitive function. Norepinephrine is also a powerful antidepressant, and it has been shown to improve mood in patients with depression. However, it is important to note that Modalert can increase blood pressure and heart rate, so people with high blood pressure should take it carefully.
Another way that norepinephrine enhances alertness is by facilitating synaptic release of glutamate onto medial prefrontal cortex pyramidal cells, which can block by the NE-selective neurotoxin DSP-4 (which leaves DA neurons intact). Modafinil’s wake-promoting effects are also blunt in mice with defective dopamine transporter function.
Modafinil Increases Dopamine Levels
Modalert has show to increase levels of the dopamine neurotransmitter by inhibiting the transporter that removes it from brain cells. This leads to increased availability of dopamine and improves cognitive function. Studies have also shown that Modalert 200 Australia increases histamine levels in the prefrontal cortex, which can help improve attention and inhibition.
Modalert 200 mg Tablet is not suitable for use by people with severe hepatic impairment because it can cause serious side effects. People should avoid driving, operating machinery, or drinking alcohol while taking this medicine.
Modafinil increases GABA levels.
Modafinil is also able to enhance working memory performance, especially under stressful conditions. It does so by reducing the speed-accuracy trade-off of working memory tasks. In one study, a single dose of Modafinil significantly improved performance on a delayed nonmatching to position task. Another study found that modafinil improved performance on a serial reversal discrimination task.
The vigilance-promoting effects of modafinil may mediate through activation of the hypothalamus (tuberomammillary nucleus and orexin neurons in the perifornical area) and the prefrontal cortex. Moreover, it may also be a selective alpha-1-adrenergic receptor agonist.
People should not take Modalert with severe depression or mania. It can also cause heart problems. If you are a sportsperson, do not take this medicine during a sporting event, as it can lead to drowsiness. Do not stop taking this medicine without consulting your doctor. Sudden discontinuation can reduce its effectiveness and cause your sleepiness to return.
